is my system of choice now... I have a number of the various books including such things as Biotech, Compendium I and II, Cyberpunk, Imperial Rome, Fantasy Bestiary, Grimoire, Mage the Ascension, Magic, Mecha, Psionics, Robots, Space, Traveller, Traveller: Star Mercs, Vampire the Masquerade, Vampire Player Guide, Vehicles... erm, they're the ones that spring to mind. So I kind of like the system!
It's not the best in the world, but it does what I need it to do. (And, yes, I subscribe to Pyramid
You might be interested in the webpage information for my interpretation of the Rogue Trader universe (link to the left)... I take a bit more of a sci-fi approach, but am beginning to incorporate some more 'fantastical' elements (i.e. a type of 'sorcery' for powerful psionicists)...