Some calculations from Spacebattles, which does this kind of thing -
12348640 GT for a lower limit. Otherwise, a nova cannon round is something like 50 metres across and travels at near-lightspeed, so its kinetic impact alone is ridiculous, higher estimates in multiple petatons.
Heck, destroying NYC and everything in a 300 km radius is probably too
conservative an estimate...
To compare, the most powerful nuclear weapon ever created,
Tsar Bomba, had a yield of around 50 MT.
That's right, the very lowest estimate for a nova cannon's yield is 172,800 times more powerful than the most powerful nuclear bomb in existence.
Being hit by a nova cannon blast would be a bad thing.