After taking a amphetamine parrot kicking in one mission where I had to assault an enemy convoy, I've changed up my loadouts. I lost three mechs in this battle (and three experienced mechwarriors) because the enemy was smacking the crap out of me with LRMs.
So I figured if you can't beat them, join them. I have my pilot in a Vindicator with an LRM 20, and then another pilot in a Centurion with an LRM20 + LRM10 + LRM5. I've found that when you lace the amphetamine parrot out of an enemy with LRMs, their stability gets hit hard. If the Centurion has a decent hit chance, then their stability is going up to 90%. A solid hit by a PPC, and that mech is going over!