Against Orks, you need to make a gunline and shoot him to death before his Boyz get to your line. Intercept his Nobz with your Terminators. Be sure to do everything you can to get the assault rather than letting him have it. Back up as you shoot until you can move forward and assault him. Use Combat Squads to Speed Bump his large squads of Boyz so that the rest of your force can get another round of shooting at them.
Next, buy some Rhinos for your Tactical Squads and, maybe, a drop Pod or two for your Dreads.
Also, move this thread to the Space Marine Tactics and Armylists Forum for more specific advice.
NewHeretic