I can definitely see how having make and female parts on the same sprue, can be difficult for making best use of multi-part kits.
It would limit the interchangeability a bit. But I think it would have been doable with the Orlock models; their clothing is loose enough that you don't need to really exaggerate the hips or anything. All you'd really need would be a swappable chest piece for a couple of the torsos that gave you the option of having breasts on the model, and a few heads with more feminine facial features + hair. A female Juve could be fairly boy-shaped, given how humans tend to mature, so you could even use a female head on a male body and it wouldn't be outrageously out of place. None of the arms on the Orlock models seem gendered, so there wouldn't be any issues there either.
More on-topic, I picked up my pre-order from GW yesterday and had a look at the contents. I was slightly saddened by the fact that the Escher models are all wearing heels. Is practical footwear for women impossible to find in the 41st Millennium? I mean, they're better than the nonsense shoes Inquisitor Greyfax has, but still. Some flat-soled Doc Marten style boots would have been nice on at least a few of the Escher bodies, and would stil work with the 80s punk rock aesthetic.
The weapon options on the Goliath and Escher kits are pretty nice. I haven't had a chance to put anything together, so I don't know how truly interchangeable everything is, or if they're more like the new Primaris models where only certain pairs of arms will fit well on specific torsos. I'm hoping it's the former, but expecting to be disappointed to find out it's the latter.
I'm torn on the sculpted bases. I was planning on basing my gangs with my usual urban style I've been using on my Deathwatch models
, but that would now require buying more plain bases. The detail on the sculpted bases is okay, but I think it's lacking compared to the Sector Mechanicus bases, or what you can to on your own with some time, glue, and basing supplies.
Before they'd announced that Necromunda was returning (and even before Shadow War: Armageddon) I'd started converting a gang out of the Genestealer Cultist models. Their bald heads and goggles made me think of the old Delaque models, but with Van Saar style enviro-suits. I may see about borrowing some unused parts from my new Goliath and Escher gangs to flesh them out some more, and have some kind of customized gang too. Not sure which house rules to use but there are official options